D
IPR011611

Carbohydrate kinase PfkB

InterPro entry
Short namePfkB_dom
Overlapping
homologous
superfamilies
 
Ribokinase-like (IPR029056)
domain relationships

Description

This domain is found in a variety of carbohydrate and pyrimidine kinases. It is found in phosphomethylpyrimidine kinase (
2.7.4.7
), which is part of the thiamine pyrophosphate (TPP) synthesis pathway -TPP being an essential cofactor for many enzymes
[1]
. It is also found in 2-keto-3-deoxygluconate kinase, which is a component of the Entner-Doudoroff pathway in hyperthermophilic archaea
[2]
.

References

1.Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures. Sigrell JA, Cameron AD, Jones TA, Mowbray SL. Structure 6, 183-93, (1998). View articlePMID: 9519409

2.The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation. Ahmed H, Ettema TJ, Tjaden B, Geerling AC, van der Oost J, Siebers B. Biochem. J. 390, 529-40, (2005). PMID: 15869466

Cross References

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