D
IPR011620

Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region

InterPro entry
Short nameSig_transdc_His_kinase_LytS_TM

Description

Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms
[6, 1]
. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation
[5]
, and CheA, which plays a central role in the chemotaxis system
[2]
. Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain, but other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP, the phosphotransfer from the kinase to an aspartate of the response regulator, and (with bifunctional enzymes) the phosphotransfer from aspartyl phosphate back to ADP or to water
[4]
. The kinase core has a unique fold, distinct from that of the Ser/Thr/Tyr kinase superfamily.

This entry represents the transmembrane region of the 5TM-Lyt (5TM Receptors of the LytS-YhcK type) histidine kinase
[3]
. The two-component regulatory system LytS/LytT probably regulates genes involved in cell wall metabolism.

References

1.Histidine kinases and response regulator proteins in two-component signaling systems. West AH, Stock AM. Trends Biochem. Sci. 26, 369-76, (2001). View articlePMID: 11406410

2.Structure of CheA, a signal-transducing histidine kinase. Bilwes AM, Alex LA, Crane BR, Simon MI. Cell 96, 131-41, (1999). View articlePMID: 9989504

3.Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria. Anantharaman V, Aravind L. BMC Genomics 4, 34, (2003). View articlePMID: 12914674

4.Bacteriophytochromes: new tools for understanding phytochrome signal transduction. Vierstra RD, Davis SJ. Semin. Cell Dev. Biol. 11, 511-21, (2000). View articlePMID: 11145881

5.Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. Tomomori C, Tanaka T, Dutta R, Park H, Saha SK, Zhu Y, Ishima R, Liu D, Tong KI, Kurokawa H, Qian H, Inouye M, Ikura M. Nat. Struct. Biol. 6, 729-34, (1999). View articlePMID: 10426948

6.Protein aspartate phosphatases control the output of two-component signal transduction systems. Perego M, Hoch JA. Trends Genet. 12, 97-101, (1996). View articlePMID: 8868347

Further reading

7. Communication modules in bacterial signaling proteins. Parkinson JS, Kofoid EC. Annu. Rev. Genet. 26, 71-112, (1992). View articlePMID: 1482126

8. Protein histidine kinases and signal transduction in prokaryotes and eukaryotes. Alex LA, Simon MI. Trends Genet. 10, 133-8, (1994). View articlePMID: 8029829

9. Two-component signal transduction. Stock AM, Robinson VL, Goudreau PN. Annu. Rev. Biochem. 69, 183-215, (2000). View articlePMID: 10966457

GO terms

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.