D
IPR011651

Notch ligand, N-terminal domain

InterPro entry
Short nameNotch_ligand_N

Description

This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins, including Delta-like protein 1 (DLL1), 4 (DLL4) and Protein jagged-1. It plays a role in lipid binding
[1, 2, 3]
.

References

1.Notch ligand delta-like1: X-ray crystal structure and binding affinity. Kershaw NJ, Church NL, Griffin MD, Luo CS, Adams TE, Burgess AW. Biochem. J. 468, 159-66, (2015). View articlePMID: 25715738

2.Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC. Science 347, 847-53, (2015). View articlePMID: 25700513

3.Structural analysis uncovers lipid-binding properties of Notch ligands. Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM. Cell Rep 5, 861-7, (2013). PMID: 24239355

GO terms

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