Pseudouridine synthase, TruD, insertion domain
Short name | PsdUridine_synth_TruD_insert |
Overlapping homologous superfamilies |
Description
* Pseudouridine synthase I, TruA.
* Pseudouridine synthase II, TruB, which contains and additional C-terminal PUA domain.
* Pseudouridine synthase RsuA. RluB, RluE and RluF are also part of this family.
* Pseudouridine synthase RluA. TruC, RluC and RluD belong to this family.
* Pseudouridine synthase TruD, which has a natural circular permutation in the catalytic domain, as well as an insertion of a family-specific α+β subdomain.
References
1.A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya. Kaya Y, Ofengand J. RNA 9, 711-21, (2003). View articlePMID: 12756329
2.Role of cysteine residues in pseudouridine synthases of different families. Ramamurthy V, Swann SL, Spedaliere CJ, Mueller EG. Biochemistry 38, 13106-11, (1999). View articlePMID: 10529181
3.X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold. Ericsson UB, Nordlund P, Hallberg BM. FEBS Lett. 565, 59-64, (2004). View articlePMID: 15135053
4.Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold. Hoang C, Ferre-D'Amare AR. RNA 10, 1026-33, (2004). View articlePMID: 15208439
5.Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases. Chan CM, Huang RH. Arch. Biochem. Biophys. 489, 15-9, (2009). View articlePMID: 19664587
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PROSITE profiles:PS50984