F
IPR011841

Type III secretion system, needle protein

InterPro entry
Short nameT3SS_needle_YscF
Overlapping
homologous
superfamilies
 
family relationships

Description

Type III secretion systems translocate proteins, usually virulence factors, out across both inner and outer membranes of certain Gram-negative bacteria and further across the plasma membrane and into the cytoplasm of the host cell. This protein, termed YscF in Yersinia, and EscF, PscF, EprI, etc. in other systems, forms the needle of the injection apparatus
[1]
. The structure of PscF has been revealed
[3, 2]
.

References

1.Genetic analysis of the formation of the Ysc-Yop translocation pore in macrophages by Yersinia enterocolitica: role of LcrV, YscF and YopN. Marenne MN, Journet L, Mota LJ, Cornelis GR. Microb. Pathog. 35, 243-58, (2003). View articlePMID: 14580388

2.A Structure-Function-Inhibition Analysis of the P. aeruginosa Type III Secretion Needle Protein PscF. Moir DT, Bowlin NO, Berube BJ, Yabut J, Mills DM, Nguyen GT, Aron ZD, Williams JD, Mecsas J, Hauser AR, Bowlin TL. J. Bacteriol. (2020). PMID: 32601072

3.Structural and Functional Characterization of the Type Three Secretion System (T3SS) Needle of Pseudomonas aeruginosa. Lombardi C, Tolchard J, Bouillot S, Signor L, Gebus C, Liebl D, Fenel D, Teulon JM, Brock J, Habenstein B, Pellequer JL, Faudry E, Loquet A, Attree I, Dessen A, Job V. Front Microbiol 10, 573, (2019). PMID: 31001211

GO terms

Cross References

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