F
IPR012101

Biotinidase-like, eukaryotic

InterPro entry
Short nameBiotinidase-like_euk
Overlapping
homologous
superfamilies
 
family relationships

Description

These secondary amidases participate in vitamin recycling. Biotinidase (
3.5.1.12
) has both a hydrolase and a transferase activity. It hydrolyzes free biocytin or small biotinyl-peptides produced during the proteolytic degradation of biotin-dependent carboxylases, to release free biotin (vitamin H), and it can transfer biotin to acceptor molecules such as histones. Biotinidase deficiency in humans is an autosomal recessive disorder characterized by neurological and cutaneous symptoms
[1]
.

References

1.Impaired biotinidase activity disrupts holocarboxylase synthetase expression in late onset multiple carboxylase deficiency. Perez-Monjaras A, Cervantes-Roldan R, Meneses-Morales I, Gravel RA, Reyes-Carmona S, Solorzano-Vargas S, Gonzalez-Noriega A, Leon-Del-Rio A. J. Biol. Chem. 283, 34150-8, (2008). View articlePMID: 18845537

Further reading

2. Catalysis in the nitrilase superfamily. Brenner C. Curr. Opin. Struct. Biol. 12, 775-82, (2002). View articlePMID: 12504683

3. Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores. Martin F, Penet MF, Malergue F, Lepidi H, Dessein A, Galland F, de Reggi M, Naquet P, Gharib B. J. Clin. Invest. 113, 591-7, (2004). View articlePMID: 14966568

4. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice. Pitari G, Malergue F, Martin F, Philippe JM, Massucci MT, Chabret C, Maras B, Dupre S, Naquet P, Galland F. FEBS Lett. 483, 149-54, (2000). View articlePMID: 11042271

5. The nitrilase superfamily: classification, structure and function. Pace HC, Brenner C. Genome Biol. 2, REVIEWS0001, (2001). View articlePMID: 11380987

6. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. Jansen PA, Kamsteeg M, Rodijk-Olthuis D, van Vlijmen-Willems IM, de Jongh GJ, Bergers M, Tjabringa GS, Zeeuwen PL, Schalkwijk J. J. Invest. Dermatol. 129, 2167-74, (2009). View articlePMID: 19322213

GO terms

Cross References

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