D
IPR012419

Cas1p, 10 TM acyl transferase domain

InterPro entry
Short nameCas1_AcylTrans_dom

Description

Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence
[2]
. This entry represents the multi TM domain of the Cas1p, which was unified with the 10 TM Sugar Acyltransferase superfamily
[1]
. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family
[1]
. The Cas1p protein has a N-terminal PC-esterase domain with the opposing acyl esterase activity
[1]
.

References

1.Novel eukaryotic enzymes modifying cell-surface biopolymers. Anantharaman V, Aravind L. Biol. Direct 5, 1, (2010). View articlePMID: 20056006

2.Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide. Janbon G, Himmelreich U, Moyrand F, Improvisi L, Dromer F. Mol. Microbiol. 42, 453-67, (2001). View articlePMID: 11703667

Cross References

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