IPR012419
Cas1p, 10 TM acyl transferase domain
InterPro entry
Short name | Cas1_AcylTrans_dom |
Description
Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence
[2]. This entry represents the multi TM domain of the Cas1p, which was unified with the 10 TM Sugar Acyltransferase superfamily
[1]. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family
[1]. The Cas1p protein has a N-terminal PC-esterase domain with the opposing acyl esterase activity
[1].
References
1.Novel eukaryotic enzymes modifying cell-surface biopolymers. Anantharaman V, Aravind L. Biol. Direct 5, 1, (2010). View articlePMID: 20056006
2.Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide. Janbon G, Himmelreich U, Moyrand F, Improvisi L, Dromer F. Mol. Microbiol. 42, 453-67, (2001). View articlePMID: 11703667
Cross References
Contributing Member Database Entry
- Pfam:PF07779