D
IPR012920

Ribosomal RNA methyltransferase, SPB1-like, C-terminal

InterPro entry
Short namerRNA_MeTfrase_SPB1-like_C

Description

This domain is found at the C terminus SPB1-like proteins. This domain interacts with the meandering tail of Erb1 and its removal is required to form the pre-mature inter-subunit surface of the Arx1/Nog2 particle
[5, 4]
.

SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit
[1]
. In Saccharomyces cerevisiae, it specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation
[2]
. It interacts with the snoRNA-associated proteins Nop1 and Nop58
[3]
.

References

1.Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Kressler D, Rojo M, Linder P, Cruz J. Nucleic Acids Res. 27, 4598-608, (1999). View articlePMID: 10556316

2.Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Lapeyre B, Purushothaman SK. Mol. Cell 16, 663-9, (2004). View articlePMID: 15546625

3.Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind S-adenosyl-L-methionine in vitro. Pintard L, Kressler D, Lapeyre B. Mol. Cell. Biol. 20, 1370-81, (2000). View articlePMID: 10648622

4.Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R. Cell 171, 1599-1610.e14, (2017). PMID: 29245012

5.Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. Kater L, Mitterer V, Thoms M, Cheng J, Berninghausen O, Beckmann R, Hurt E. Mol Cell 79, 615-628.e5, (2020). PMID: 32668200

Further reading

6. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. Morello LG, Coltri PP, Quaresma AJ, Simabuco FM, Silva TC, Singh G, Nickerson JA, Oliveira CC, Moore MJ, Zanchin NI. PLoS ONE 6, e29174, (2011). View articlePMID: 22195017

GO terms

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.