D
IPR012943

Centrosomin, N-terminal motif 1

InterPro entry
Short nameCnn_1N

Description

This domain (Cnn_1N) is a short conserved motif found in the N-terminal of a group of centrosome or spindle pole body (SPB) associated proteins, including Mto1 and Pcp1 from S. pombe
[6, 4]
, centrosomin from flies
[3, 5]
and myomegalin/CDK5RAP2 from mammals
[1, 2]
.

References

1.Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. Graser S, Stierhof YD, Nigg EA. J. Cell. Sci. 120, 4321-31, (2007). View articlePMID: 18042621

2.Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, Onuffer J, Jin SL, Conti M. J. Biol. Chem. 276, 11189-98, (2001). View articlePMID: 11134006

3.The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila. Megraw TL, Li K, Kao LR, Kaufman TC. Development 126, 2829-39, (1999). PMID: 10357928

4.Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. Flory MR, Morphew M, Joseph JD, Means AR, Davis TN. Cell Growth Differ. 13, 47-58, (2002). PMID: 11864908

5.The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation. Conduit PT, Feng Z, Richens JH, Baumbach J, Wainman A, Bakshi SD, Dobbelaere J, Johnson S, Lea SM, Raff JW. Dev. Cell 28, 659-69, (2014). View articlePMID: 24656740

6.Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function. Venkatram S, Tasto JJ, Feoktistova A, Jennings JL, Link AJ, Gould KL. Mol. Biol. Cell 15, 2287-301, (2004). View articlePMID: 15004232

Further reading

7. Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1. Zhang J, Megraw TL. Mol. Biol. Cell 18, 4037-49, (2007). View articlePMID: 17671162

GO terms

biological process

  • None

molecular function

  • None
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