D
IPR013013

Phosphotransferase system, EIIC component, type 1

InterPro entry
Short namePTS_EIIC_1
domain relationships

Description

According to sequence analyses
[1, 4, 5]
, the PTS EIIC domain can be divided in five groups:
 * The PTS EIIC type 1 domain is found in the Glucose class of PTS and has an average length of about 80 amino acids.
 * The PTS EIIC type 2 domain is found in the Mannitol class of PTS and has an average length of about 90 amino acids.
 * The PTS EIIC type 3 domain is found in the Lactose class of PTS and has an average length of about 100 amino acids.
 * The PTS EIIC type 4 domain is found in the Mannose class of PTS and has an average length of about 160 amino acids.
 * The PTS EIIC type 5 domain is found in the Sorbitol class of PTS and has an average length of about 190 amino acids.

This entry represents the type 1 domain.

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)
[1, 2]
is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars.

The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred via a signal transduction pathway, to enzyme I (EI) which in turn transfers it to a phosphoryl carrier, the histidine protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease, a membrane-bound complex known as enzyme 2 (EII), which transports the sugar to the cell. EII consists of at least three structurally distinct domains IIA, IIB and IIC
[3]
. These can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII).

References

1.Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria. Postma PW, Lengeler JW, Jacobson GR. Microbiol. Rev. 57, 543-94, (1993). View articlePMID: 8246840

2.The bacterial phosphoenolpyruvate: glycose phosphotransferase system. Meadow ND, Fox DK, Roseman S. Annu. Rev. Biochem. 59, 497-542, (1990). View articlePMID: 2197982

3.Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Saier MH Jr, Reizer J. J. Bacteriol. 174, 1433-8, (1992). View articlePMID: 1537788

4.The bacterial phosphotransferase system: new frontiers 30 years later. Saier MH Jr, Reizer J. Mol. Microbiol. 13, 755-64, (1994). View articlePMID: 7815935

5.The complete phosphotranferase system in Escherichia coli. Tchieu JH, Norris V, Edwards JS, Saier MH Jr. J. Mol. Microbiol. Biotechnol. 3, 329-46, (2001). PMID: 11361063

Cross References

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