D
IPR013222

Glycosyl hydrolase family 98, putative carbohydrate-binding module

InterPro entry
Short nameGlyco_hyd_98_carb-bd
Overlapping
homologous
superfamilies
 

Description

This entry represents a putative carbohydrate binding module (NPCBM) domain found at the N terminus of glycosyl hydrolase family 98 proteins
[2]
.

Proteins containing this domain include CpGH98 from C. perfringens. It specifically hydrolyses fucose-containing trisaccharides from the glycotopes of blood groups A and B and is implicated for the infectivity and virulence of this pathogen
[1]
. CpGH98 has a central TIM barrel catalytic domain, in which putative catalytic residues may be tentatively identified, and an N-terminal novel putative carbohydrate binding module (NPCBM)
[1]
.

NPCBM domains found in bacterial conflict systems are predicted to interact with invasive molecules and recruit downstream effectors
[3]
.

References

1.A clostridial endo-beta-galactosidase that cleaves both blood group A and B glycotopes: the first member of a new glycoside hydrolase family, GH98. Anderson KM, Ashida H, Maskos K, Dell A, Li SC, Li YT. J. Biol. Chem. 280, 7720-8, (2005). View articlePMID: 15618227

2.Analysis of glycoside hydrolase family 98: catalytic machinery, mechanism and a novel putative carbohydrate binding module. Rigden DJ. FEBS Lett. 579, 5466-72, (2005). View articlePMID: 16212961

3.Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans. Kaur G, Iyer LM, Burroughs AM, Aravind L. Elife 10, (2021). PMID: 34061031

Cross References

Contributing Member Database Entries
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.