F
IPR013288

Cytochrome c oxidase subunit IV

InterPro entry
Short nameCyt_c_oxidase_su4
Overlapping
homologous
superfamilies
 
family relationships

Description

Cytochrome c oxidase (COX) subunit IV is a mitochondrial inner membrane protein that forms part of the 13-subunit COX complex, the terminal oxidase in the mitochondrial electron transport chain. The enzyme catalyses the reaction:4 ferrocytochrome c + O(2) = 4 ferricytochrome c + 2 H(2)OThis polypeptide belongs to a wider family of proteins that includes the Dictyostelium discoideum (Slime mold) COX VI and the Saccharomyces cerevisiae (Baker's yeast) protein YGX6. The 3D structure of the whole bovine heart cytochrome c oxidase has been determined to 2.8A resolution by means of X-ray crystallography
[1, 2]
. The structure reveals 13 different subunits, five phosphatidyl ethanolamines, three phosphatidyl glycerols, two cholates, two haems A, and a number of copper, magnesium and zinc ions
[1]
. A hydrogen-bonded system, including a propionate of haem A, part of the peptide backbone, and an imidazole ligand of CuA, may provide an electron transfer pathway between CuA and haem A
[1]
.

References

1.The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A. Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S. Science 272, 1136-44, (1996). View articlePMID: 8638158

2.Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution. Tomizaki T, Yamashita E, Yamaguchi H, Aoyama H, Tsukihara T, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S. Acta Crystallogr. D Biol. Crystallogr. 55, 31-45, (1999). View articlePMID: 10089392

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