H
IPR013328

6-phosphogluconate dehydrogenase, domain 2

InterPro entry
Short name6PGD_dom2
Overlapping entries
 

Description

This superfamily represents a multi-helical domain found in several NAD or NADP-utilizing dehydrogenases, including 6-phosphogluconate dehydrogenase
[1]
, classes I and II ketol-acid reductoisomerases
[2]
, L-3-hydroxyacyl CoA dehydrogenase
[3]
, UDP-glucose dehydrogenase
[4]
, glycerol-3-phosphate dehydrogenase
[5]
, ketopantoate reductase
[6]
, N-(1-D-carboxylethyl)-L-norvaline dehydrogenase
[7]
, and mannitol 2-dehydrogenase
[8]
. This domain, often found in the C-terminal region of the sequence, is also found in some Cytokine-like nuclear factor N-PAC proteins, which have chromatin gene reader activity involved in chromatin modification and regulation of gene expression in humans
[10, 9]
.

References

1.Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase. Li L, Dworkowski FS, Cook PF. J. Biol. Chem. 281, 25568-76, (2006). View articlePMID: 16803886

2.The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. Tyagi R, Duquerroy S, Navaza J, Guddat LW, Duggleby RG. Protein Sci. 14, 3089-100, (2005). View articlePMID: 16322583

3.Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme. Barycki JJ, O'Brien LK, Strauss AW, Banaszak LJ. J. Biol. Chem. 276, 36718-26, (2001). View articlePMID: 11451959

4.Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis. Huh JW, Lee HJ, Choi MM, Yang SJ, Yoon SY, Kim DW, Kim SY, Choi SY, Cho SW. Bioconjug. Chem. 16, 710-6, (2005). View articlePMID: 15898741

5.Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). Ou X, Ji C, Han X, Zhao X, Li X, Mao Y, Wong LL, Bartlam M, Rao Z. J. Mol. Biol. 357, 858-69, (2006). View articlePMID: 16460752

6.The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. Biochemistry 44, 8930-9, (2005). View articlePMID: 15966718

7.Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase. Britton KL, Asano Y, Rice DW. Nat. Struct. Biol. 5, 593-601, (1998). View articlePMID: 9665174

8.NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum. Simon-Nobbe B, Denk U, Schneider PB, Radauer C, Teige M, Crameri R, Hawranek T, Lang R, Richter K, Schmid-Grendelmeier P, Nobbe S, Hartl A, Breitenbach M. J. Biol. Chem. 281, 16354-60, (2006). View articlePMID: 16608840

9.A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A. Cell Rep 27, 387-399.e7, (2019). View articlePMID: 30970244

10.LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y, Shi YG. Mol. Cell 49, 558-70, (2013). View articlePMID: 23260659

Cross References

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