F
IPR013388

Type III secretion apparatus protein OrgA/MxiK

InterPro entry
Short nameT3SS_OrgA/MxiK

Description

This protein is encoded by genes which are found in type III secretion operons, and has been shown to be essential for the invasion phenotype in Salmonella and a component of the secretion apparatus
[1]
. The protein is known as OrgA in Salmonella due to its oxygen-dependent expression pattern in which low-oxygen levels up-regulate the gene
[2]
. In Shigella it is called MxiK and has been shown to be essential for the proper assembly of the needle complex, which is the core component of type III secretion systems
[3]
. The putative uncharacterized protein YgeO from E. coli is also included in this entry. YgeO' is reported in ecogene as being homologous to OrgA and MxiK.

References

1.Transcriptional organization and function of invasion genes within Salmonella enterica serovar Typhimurium pathogenicity island 1, including the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes. Klein JR, Fahlen TF, Jones BD. Infect. Immun. 68, 3368-76, (2000). View articlePMID: 10816487

2.Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization. Jones BD, Falkow S. Infect. Immun. 62, 3745-52, (1994). View articlePMID: 8063389

3.MxiK and MxiN interact with the Spa47 ATPase and are required for transit of the needle components MxiH and MxiI, but not of Ipa proteins, through the type III secretion apparatus of Shigella flexneri. Jouihri N, Sory MP, Page AL, Gounon P, Parsot C, Allaoui A. Mol. Microbiol. 49, 755-67, (2003). View articlePMID: 12864857

Cross References

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