D
IPR013401

Type III secretion regulator, YopN/LcrE/InvE/MxiC

InterPro entry
Short nameT3SS_LcrE
domain relationships

Description

This protein is found in type III secretion operons and, in Yersinia, is localized to the cell surface and is involved in the Low-Calcium Response (LCR), possibly by sensing the calcium concentration
[1]
. In Salmonella, the gene is known as InvE and is believed to perform an essential role in the secretion process and interacts with the proteins SipBCD and SicA
[2]
. Negative regulation of type III secretion in Yersinia pestis is mediated in part by a multiprotein complex that has been proposed to act as a physical impediment to type III secretion by blocking the entrance to the secretion apparatus prior to contact with mammalian cells. This complex is composed of YopN, its heterodimeric secretion chaperone SycN-YscB, and TyeA
[3, 4, 5]
.

References

1.The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis. Forsberg A, Viitanen AM, Skurnik M, Wolf-Watz H. Mol. Microbiol. 5, 977-86, (1991). View articlePMID: 1857212

2.Salmonella type III secretion-associated protein InvE controls translocation of effector proteins into host cells. Kubori T, Galan JE. J. Bacteriol. 184, 4699-708, (2002). View articlePMID: 12169593

3.Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis. Schubot FD, Jackson MW, Penrose KJ, Cherry S, Tropea JE, Plano GV, Waugh DS. J. Mol. Biol. 346, 1147-61, (2005). View articlePMID: 15701523

4.Structures of the Shigella flexneri type 3 secretion system protein MxiC reveal conformational variability amongst homologues. Deane JE, Roversi P, King C, Johnson S, Lea SM. J. Mol. Biol. 377, 985-92, (2008). View articlePMID: 18304577

5.Biochemical and structural insights into microtubule perturbation by CopN from Chlamydia pneumoniae. Nawrotek A, Guimaraes BG, Velours C, Subtil A, Knossow M, Gigant B. J Biol Chem 289, 25199-210, (2014). PMID: 25056950

GO terms

Cross References

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