D
IPR013600

Ly49-like, N-terminal

InterPro entry
Short nameLy49_N

Description

The sequences making up this entry are annotated as, or are similar to, Ly49 receptors (e.g.
P20937
). These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function
[1]
. They are members of the C-type lectin receptor superfamily
[2]
, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (
IPR001304
).

References

1.Mouse Ly49 NK receptors: balancing activation and inhibition. Ortaldo JR, Young HA. Mol. Immunol. 42, 445-50, (2005). View articlePMID: 15607796

2.Ly-49P activates NK-mediated lysis by recognizing H-2Dd. Silver ET, Gong DE, Chang CS, Amrani A, Santamaria P, Kane KP. J. Immunol. 165, 1771-81, (2000). View articlePMID: 10925254

Contributing Member Database Entry
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