D
IPR013612

Amino acid permease, N-terminal

InterPro entry
Short nameAA_permease_N

Description

Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related
[1, 2, 3]
. These proteins appear to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second transmembrane segment. This domain is found to the N terminus of the amino acid permease domain (
IPR004841
) in metazoan Na-K-Cl cotransporters.

References

1.Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae. Weber E, Chevallier MR, Jund R. J. Mol. Evol. 27, 341-50, (1988). View articlePMID: 3146645

2.Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. Vandenbol M, Jauniaux JC, Grenson M. Gene 83, 153-9, (1989). View articlePMID: 2687114

3.Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. Reizer J, Finley K, Kakuda D, MacLeod CL, Reizer A, Saier MH Jr. Protein Sci. 2, 20-30, (1993). View articlePMID: 8382989

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