D
IPR013855

Cdc37, N-terminal domain

InterPro entry
Short nameCdc37_N_dom

Description

Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the N-terminal kinase binding domain of these proteins
[1]
. It is found N-terminal to a Hsp90 chaperone (heat shock protein 90) binding domain (
IPR013874
). Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 has been shown to result in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function
[1]
.

References

1.Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90. Turnbull EL, Martin IV, Fantes PA. FEBS J. 272, 4129-40, (2005). View articlePMID: 16098195

GO terms

biological process

  • None

cellular component

  • None
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