IPR013874
Cdc37, Hsp90 binding
InterPro entry
Short name | Cdc37_Hsp90-bd |
Overlapping homologous superfamilies |
Description
Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the Hsp90 chaperone (heat shock protein 90) binding domain of Cdc37
[1]. It is found between the N-terminal Cdc37 domain (
IPR013855), which is predominantly involved in kinase binding, and the C-terminal domain of Cdc37 (
IPR013873) whose function is unclear.
References
1.Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90. Turnbull EL, Martin IV, Fantes PA. FEBS J. 272, 4129-40, (2005). View articlePMID: 16098195
Representative structure
2w0g: HSP90 CO-CHAPERONE CDC37