D
IPR013874

Cdc37, Hsp90 binding

InterPro entry
Short nameCdc37_Hsp90-bd
Overlapping
homologous
superfamilies
 

Description

Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the Hsp90 chaperone (heat shock protein 90) binding domain of Cdc37
[1]
. It is found between the N-terminal Cdc37 domain (
IPR013855
), which is predominantly involved in kinase binding, and the C-terminal domain of Cdc37 (
IPR013873
) whose function is unclear.

References

1.Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90. Turnbull EL, Martin IV, Fantes PA. FEBS J. 272, 4129-40, (2005). View articlePMID: 16098195

Contributing Member Database Entries
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