H
IPR013986

DExx box DNA helicase domain superfamily

InterPro entry
Short nameDExx_box_DNA_helicase_dom_sf
Overlapping entries
 

Description

This domain superfamily is found in DExx type DNA helicases, such as the hexameric essential helicases PcrA from Gram-positive bacteria and Rep and UvrD from Gram-negative bacteria
[4]
. PcrA is essential for cell growth in Bacillus species, as it is required for rolling circle replication, unwinding DNA using an active inchworm mechanism
[1]
. UvrD from Escherichia coli is a superfamily 1 (SF1) helicase involved in several DNA metabolic processes, including recombination and repair
[2]
, while Rep affects the rate of replication fork progression in E. coli and is required for the replication of certain phages
[3]
. The domain is also found in the exodeoxyribonuclease V gamma chain, which has a wide variety of catalytic activities including ATP-dependent exonuclease, ATP-stimulated endonuclease, ATP-dependent helicase and DNA-dependent ATPase activities.

References

1.Directional loading and stimulation of PcrA helicase by the replication initiator protein RepD. Zhang W, Dillingham MS, Thomas CD, Allen S, Roberts CJ, Soultanas P. J. Mol. Biol. 371, 336-48, (2007). View articlePMID: 17574572

2.A nonuniform stepping mechanism for E. coli UvrD monomer translocation along single-stranded DNA. Tomko EJ, Fischer CJ, Niedziela-Majka A, Lohman TM. Mol. Cell 26, 335-47, (2007). View articlePMID: 17499041

3.Rep helicase suppresses short-homology-dependent illegitimate recombination in Escherichia coli. Shiraishi K, Imai Y, Yoshizaki S, Ikeda H. Genes Cells 10, 1015-23, (2005). View articlePMID: 16236131

4.Essential bacterial helicases that counteract the toxicity of recombination proteins. Petit MA, Ehrlich D. EMBO J. 21, 3137-47, (2002). View articlePMID: 12065426

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.