D
IPR014010

REJ domain

InterPro entry
Short nameREJ_dom

Description

The REJ domain is an extracellular module of ~700 amino acids, which is found associated with other domains, such as EGF, the GPS proteolytic cleavage site, C-type lectin, SUEL-type lectin, LRR, LDL-A, PLAT, PKD
[1, 2, 4]
. Although its function is unknown, the REJ domain has been shown to be required for cleavage to occur at the GPS
[3]
. It has been proposed that the REJ domain might function in ion transport homeostasis
[1]
. REJ domain from Polycystin-1 is required for cleavage at the G-protein coupled proteolytic site (GPS) or the ectodomain, a process that is essential for kidney structure and function
[4]
.

References

1.The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1. Moy GW, Mendoza LM, Schulz JR, Swanson WJ, Glabe CG, Vacquier VD. J. Cell Biol. 133, 809-17, (1996). View articlePMID: 8666666

2.Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. Sandford R, Sgotto B, Aparicio S, Brenner S, Vaudin M, Wilson RK, Chissoe S, Pepin K, Bateman A, Chothia C, Hughes J, Harris P. Hum. Mol. Genet. 6, 1483-9, (1997). View articlePMID: 9285785

3.Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Qian F, Boletta A, Bhunia AK, Xu H, Liu L, Ahrabi AK, Watnick TJ, Zhou F, Germino GG. Proc. Natl. Acad. Sci. U.S.A. 99, 16981-6, (2002). View articlePMID: 12482949

4.Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy Techniques. Xu M, Ma L, Bujalowski PJ, Qian F, Sutton RB, Oberhauser AF. J Biophys 2013, 525231, (2013). PMID: 23762046

Cross References

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