D
IPR014162

Cell division coordinator CpoB, C-terminal

InterPro entry
Short nameCpoB_C
Overlapping
homologous
superfamilies
 

Description

Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF, which is then renamed CpoB (Coordinator of PG synthesis and OM constriction, associated with PBP1B). All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, and a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction
[1]
.

Escherichia CpoB coordinates PBP1B and the Tol machines to maintain cell envelope integrity during division
[2]
.

References

1.Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence. Dubuisson JF, Vianney A, Hugouvieux-Cotte-Pattat N, Lazzaroni JC. Microbiology (Reading, Engl.) 151, 3337-47, (2005). View articlePMID: 16207916

2.Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division. Gray AN, Egan AJ, Van't Veer IL, Verheul J, Colavin A, Koumoutsi A, Biboy J, Altelaar AF, Damen MJ, Huang KC, Simorre JP, Breukink E, den Blaauwen T, Typas A, Gross CA, Vollmer W. Elife 4, (2015). View articlePMID: 25951518

Cross References

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