D
IPR014890

c-SKI SMAD4-binding domain

InterPro entry
Short namec-SKI_SMAD4-bd_dom
Overlapping
homologous
superfamilies
 

Description

This entry represents the SMAD4-binding domain of c-SKI, which is an oncogene that inhibits TGF-beta signalling through interaction with SMAD proteins
[1, 2]
.

References

1.c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements. Suzuki H, Yagi K, Kondo M, Kato M, Miyazono K, Miyazawa K. Oncogene 23, 5068-76, (2004). View articlePMID: 15107821

2.Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y. Cell 111, 357-67, (2002). View articlePMID: 12419246

GO terms

biological process

  • None

molecular function

cellular component

  • None
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