D
IPR015168

SsuA/THI5-like

InterPro entry
Short nameSsuA/THI5

Description

This domain is found in NMT1/THI5 family proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine
[1, 2, 3]
. This domain is also found in aliphatic sulfonates-binding protein SsuA, which is part of a transport system for aliphatic sulfonates
[4]
.

References

1.Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Rodriguez-Navarro S, Llorente B, Rodriguez-Manzaneque MT, Ramne A, Uber G, Marchesan D, Dujon B, Herrero E, Sunnerhagen P, Perez-Ortin JE. Yeast 19, 1261-76, (2002). View articlePMID: 12271461

2.nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine. Maundrell K. J. Biol. Chem. 265, 10857-64, (1990). View articlePMID: 2358444

3.The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Wightman R, Meacock PA. Microbiology (Reading, Engl.) 149, 1447-60, (2003). View articlePMID: 12777485

4.The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl. van Der Ploeg JR, Iwanicka-Nowicka R, Bykowski T, Hryniewicz MM, Leisinger T. J. Biol. Chem. 274, 29358-65, (1999). View articlePMID: 10506196

Cross References

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