F
IPR015615

Transforming growth factor-beta-related

InterPro entry
Short nameTGF-beta-rel
family relationships

Description

The transforming growth factor (TGF)-beta superfamily of cytokines is comprised of a number of structurally related, secreted polypeptides that regulate a multitude of cellular processes including proliferation, differentiation and neoplastic transformation
[1, 3]
. Family members include the activins/inhibins, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and TGF-betas
[3, 2]
. These growth regulatory molecules induce ligand-mediated hetero-oligomerization of distinct type II and type I serine/threonine kinase receptors that transmit signals predominantly through receptor-activated Smad proteins
[4]
but also induce Smad-independent pathways.

References

1.Transforming Growth Factor-beta superfamily: evaluation as breast cancer biomarkers and preventive agents. Gupta V, Harkin DP, Kawakubo H, Maheswaran S. 4, 165-82, (2004). View articlePMID: 15032667

2.Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Tsuchida K. Curr. Drug Targets Immune Endocr. Metabol. Disord. 4, 157-66, (2004). View articlePMID: 15180456

3.Prodomain-growth factor swapping in the structure of pro-TGF-β1. Zhao B, Xu S, Dong X, Lu C, Springer TA. J Biol Chem 293, 1579-1589, (2018). PMID: 29109152

4.TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation. Kim JH, Ham S, Lee Y, Suh GY, Lee YS. Cell Death Dis 10, 92, (2019). PMID: 30696809

GO terms

biological process

  • None

molecular function

  • None
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