IPR015615
Transforming growth factor-beta-related
InterPro entry
Short name | TGF-beta-rel |
family relationships |
Description
The transforming growth factor (TGF)-beta superfamily of cytokines is comprised of a number of structurally related, secreted polypeptides that regulate a multitude of cellular processes including proliferation, differentiation and neoplastic transformation
[1, 3]. Family members include the activins/inhibins, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and TGF-betas
[3, 2]. These growth regulatory molecules induce ligand-mediated hetero-oligomerization of distinct type II and type I serine/threonine kinase receptors that transmit signals predominantly through receptor-activated Smad proteins
[4] but also induce Smad-independent pathways.
References
1.Transforming Growth Factor-beta superfamily: evaluation as breast cancer biomarkers and preventive agents. Gupta V, Harkin DP, Kawakubo H, Maheswaran S. 4, 165-82, (2004). View articlePMID: 15032667
2.Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Tsuchida K. Curr. Drug Targets Immune Endocr. Metabol. Disord. 4, 157-66, (2004). View articlePMID: 15180456
GO terms
Contributing Member Database Entry
- PANTHER:PTHR11848