IPR015878
S-adenosyl-L-homocysteine hydrolase, NAD binding domain
InterPro entry
Short name | Ado_hCys_hydrolase_NAD-bd |
Overlapping homologous superfamilies |
Description
S-adenosyl-L-homocysteine hydrolase (
3.3.1.1) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+as a cofactor.
AdoHcyase is a highly conserved protein
[1] of about 430 to 470 amino acids.
References
1.Mutational and nucleotide sequence analysis of S-adenosyl-L-homocysteine hydrolase from Rhodobacter capsulatus. Sganga MW, Aksamit RR, Cantoni GL, Bauer CE. Proc. Natl. Acad. Sci. U.S.A. 89, 6328-32, (1992). View articlePMID: 1631127