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IPR016184

Capsid/spike protein, ssDNA virus

InterPro entry
Short nameCapsid/spike_ssDNA_virus
Overlapping entries
 
Capsid protein VP4 (IPR003433)

Description

This entry represents a coat protein found in ssDNA viruses, such as the capsid protein F and the spike protein G in Microviridae
[1]
, the Parvovirus capsid protein
[2]
, the Dependovirus capsid protein
[3]
and the Densovirus capsid protein
[4]
. These proteins share a β-sandwich structure consisting of 8 β-strands in two sheets with a jelly-roll fold, although some members can have an additional 1-2 strands; characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies.

References

1.Structural studies of bacteriophage alpha3 assembly. Bernal RA, Hafenstein S, Olson NH, Bowman VD, Chipman PR, Baker TS, Fane BA, Rossmann MG. J. Mol. Biol. 325, 11-24, (2003). View articlePMID: 12473449

2.The structure of human parvovirus B19. Kaufmann B, Simpson AA, Rossmann MG. Proc. Natl. Acad. Sci. U.S.A. 101, 11628-33, (2004). View articlePMID: 15289612

3.The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy. Xie Q, Bu W, Bhatia S, Hare J, Somasundaram T, Azzi A, Chapman MS. Proc. Natl. Acad. Sci. U.S.A. 99, 10405-10, (2002). View articlePMID: 12136130

4.The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution. Simpson AA, Chipman PR, Baker TS, Tijssen P, Rossmann MG. Structure 6, 1355-67, (1998). View articlePMID: 9817847

Cross References

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