H
IPR016185

Pre-ATP-grasp domain superfamily

InterPro entry
Short namePreATP-grasp_dom_sf
Overlapping entries
 

Description

The ATP-grasp fold is one of several distinct ATP-binding folds, and is found in enzymes that catalyse the formation of amide bonds, catalysing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule
[1]
. This fold is found in many different enzyme families, including various peptide synthetases, biotin carboxylase, synapsin, succinyl-CoA synthetase, pyruvate phosphate dikinase, and glutathione synthetase, glutathionylspermidine synthase, amongst others
[2]
. These enzymes contribute predominantly to macromolecular synthesis, using ATP-hydrolysis to activate their substrates.

References

1.A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. Galperin MY, Koonin EV. Protein Sci. 6, 2639-43, (1997). View articlePMID: 9416615

2.Mutational analysis of ATP-grasp residues in the two ATP sites of Saccharomyces cerevisiae carbamoyl phosphate synthetase. Eroglu B, Powers-Lee SG. Arch. Biochem. Biophys. 407, 1-9, (2002). View articlePMID: 12392708

Cross References

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