IPR016185
Pre-ATP-grasp domain superfamily
InterPro entry
Short name | PreATP-grasp_dom_sf |
Overlapping entries |
Description
The ATP-grasp fold is one of several distinct ATP-binding folds, and is found in enzymes that catalyse the formation of amide bonds, catalysing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule
[1]. This fold is found in many different enzyme families, including various peptide synthetases, biotin carboxylase, synapsin, succinyl-CoA synthetase, pyruvate phosphate dikinase, and glutathione synthetase, glutathionylspermidine synthase, amongst others
[2]. These enzymes contribute predominantly to macromolecular synthesis, using ATP-hydrolysis to activate their substrates.
References
1.A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. Galperin MY, Koonin EV. Protein Sci. 6, 2639-43, (1997). View articlePMID: 9416615
2.Mutational analysis of ATP-grasp residues in the two ATP sites of Saccharomyces cerevisiae carbamoyl phosphate synthetase. Eroglu B, Powers-Lee SG. Arch. Biochem. Biophys. 407, 1-9, (2002). View articlePMID: 12392708
Cross References
Contributing Member Database Entry
- SUPERFAMILY:SSF52440