H
IPR016187

C-type lectin fold

InterPro entry
Short nameCTDL_fold
Overlapping entries
 
Link domain (IPR000538)
C-type lectin-like (IPR001304)

Description

Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity
[1]
, they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions
[2]
. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins
[3]
.

This entry represents a structural domain found in C-type lectins, as well as in other proteins, including:


 * The N-terminal domain of aerolysin
[4]
and the N-terminal domain of the S2/S3 subunit of pertussis toxin
[5]
.
 * The C-terminal domain of invasin
[6]
and intimin
[7]
.
 * Link domain, which includes the Link module of TSG-6
[8]
(a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal β-strand and C-terminal β-hairpin)
[9]
.
 * Endostatin
[10]
and the endostatin domain of collagen alpha 1 (XV)
[11]
, these domains being decorated with many insertions in the common fold.
 * The noncollagenous (NC1) domain of collagen IV, which consists of a duplication of the C-type lectin domain, with segment swapping within and between individual domains
[12]
.
 * Sulphatase-modifying factors (C-alpha-formyglycine-generating enzyme), where the fold is decorated with many additional structures
[13, 14]
.
 * The C-terminal domain of the major tropism determinant (Mtd), where the fold is decorated with many additional structures, and has an overall similarity to the sulphatase modifying factor family but lacking the characteristic disulphide
[15]
.

References

1.The structural basis for carbohydrate recognition by lectins. Sharon N, Lis H. Adv. Exp. Med. Biol. 491, 1-16, (2001). PMID: 14533786

2.Animal lectins: a historical introduction and overview. Kilpatrick DC. Biochim. Biophys. Acta 1572, 187-97, (2002). View articlePMID: 12223269

3.Divergent roles for C-type lectins expressed by cells of the innate immune system. McGreal EP, Martinez-Pomares L, Gordon S. Mol. Immunol. 41, 1109-21, (2004). View articlePMID: 15476922

4.Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states. Parker MW, Buckley JT, Postma JP, Tucker AD, Leonard K, Pattus F, Tsernoglou D. Nature 367, 292-5, (1994). View articlePMID: 7510043

5.Crystal structure of the pertussis toxin-ATP complex: a molecular sensor. Hazes B, Boodhoo A, Cockle SA, Read RJ. J. Mol. Biol. 258, 661-71, (1996). View articlePMID: 8637000

6.Crystal structure of invasin: a bacterial integrin-binding protein. Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ. Science 286, 291-5, (1999). View articlePMID: 10514372

7.Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex. Luo Y, Frey EA, Pfuetzner RA, Creagh AL, Knoechel DG, Haynes CA, Finlay BB, Strynadka NC. Nature 405, 1073-7, (2000). View articlePMID: 10890451

8.The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ. J. Biol. Chem. 278, 49261-70, (2003). View articlePMID: 12972412

9.Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG. Mol. Cell 13, 483-96, (2004). View articlePMID: 14992719

10.Zinc-dependent dimers observed in crystals of human endostatin. Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC. Proc. Natl. Acad. Sci. U.S.A. 95, 10443-8, (1998). View articlePMID: 9724722

11.Some questions related to melanocyte-stimulating hormone. Kastin AJ, Sandman CA, Miller LH, Schally AV. Mayo Clin. Proc. 51, 632-6, (1976). PMID: 966814

12.The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link. Than ME, Henrich S, Huber R, Ries A, Mann K, Kuhn K, Timpl R, Bourenkov GP, Bartunik HD, Bode W. Proc. Natl. Acad. Sci. U.S.A. 99, 6607-12, (2002). View articlePMID: 12011424

13.De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data. Roeser D, Dickmanns A, Gasow K, Rudolph MG. Acta Crystallogr. D Biol. Crystallogr. 61, 1057-66, (2005). View articlePMID: 16041070

14.Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme. Dickmanns A, Schmidt B, Rudolph MG, Mariappan M, Dierks T, von Figura K, Ficner R. J. Biol. Chem. 280, 15180-7, (2005). View articlePMID: 15687489

15.The C-type lectin fold as an evolutionary solution for massive sequence variation. McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P. Nat. Struct. Mol. Biol. 12, 886-92, (2005). View articlePMID: 16170324

Cross References

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