F
IPR016319

Transforming growth factor-beta

InterPro entry
Short nameTGF-beta
family relationships

Description

The transforming growth factors-beta constitute a family of multi-functional cytokines that regulate cell growth and differentiation
[1]
. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide
[2]
. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects.

References

1.Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells. Archer SJ, Bax A, Roberts AB, Sporn MB, Ogawa Y, Piez KA, Weatherbee JA, Tsang ML, Lucas R, Zheng BL. Biochemistry 32, 1152-63, (1993). View articlePMID: 8424942

2.The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors. Cheifetz S, Weatherbee JA, Tsang ML, Anderson JK, Mole JE, Lucas R, Massague J. Cell 48, 409-15, (1987). View articlePMID: 2879635

Further reading

3. Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. Daopin S, Piez KA, Ogawa Y, Davies DR. Science 257, 369-73, (1992). View articlePMID: 1631557

4. The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Mittl PR, Priestle JP, Cox DA, McMaster G, Cerletti N, Grutter MG. Protein Sci. 5, 1261-71, (1996). View articlePMID: 8819159

5. Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Hinck AP, Archer SJ, Qian SW, Roberts AB, Sporn MB, Weatherbee JA, Tsang ML, Lucas R, Zhang BL, Wenker J, Torchia DA. Biochemistry 35, 8517-34, (1996). View articlePMID: 8679613

GO terms

biological process

  • None

molecular function

  • None
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