IPR016353
Chordin
InterPro entry
Short name | Chordin |
Description
This entry represents the chordin family. Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin, a BMP inhibitor, as well as BMP-2, is expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin increases BMP-2 bioavailability. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering
[1].
References
1.Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications. Heliotis M, Tsiridis E. Arthritis Res. Ther. 10, 115, (2008). View articlePMID: 18710600
Further reading
2. A protein scaffold plays matchmaker for chordin. Harland RM. Cell 134, 718-9, (2008). View articlePMID: 18775302
3. Development of the vertebral morphogenetic field in the mouse: Interactions between Crossveinless-2 and Twisted Gastrulation. Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM. Dev. Biol. (2008). PMID: 18789316
GO terms
biological process
molecular function
- None
cellular component
- None
Contributing Member Database Entry
- PIRSF:PIRSF002496