F
IPR016353

Chordin

InterPro entry
Short nameChordin

Description

This entry represents the chordin family. Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin, a BMP inhibitor, as well as BMP-2, is expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin increases BMP-2 bioavailability. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering
[1]
.

References

1.Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications. Heliotis M, Tsiridis E. Arthritis Res. Ther. 10, 115, (2008). View articlePMID: 18710600

Further reading

2. A protein scaffold plays matchmaker for chordin. Harland RM. Cell 134, 718-9, (2008). View articlePMID: 18775302

3. Development of the vertebral morphogenetic field in the mouse: Interactions between Crossveinless-2 and Twisted Gastrulation. Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM. Dev. Biol. (2008). PMID: 18789316

GO terms

molecular function

  • None

cellular component

  • None
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