IPR016435
Diphthamide synthesis DPH1/DPH2
InterPro entry
Short name | DPH1/DPH2 |
Overlapping homologous superfamilies | |
family relationships |
Description
Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2
[1].
References
1.Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH. Mol. Cell. Biol. 24, 9487-97, (2004). View articlePMID: 15485916
2.Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H. Nature 465, 891-6, (2010). View articlePMID: 20559380
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entries
- SFLD:SFLDS00032
- Pfam:PF01866
- NCBIfam:TIGR00322
- PANTHER:PTHR10762