F
IPR016715

Platelet-activating factor acetylhydrolase-like, eukaryote

InterPro entry
Short namePAF_acetylhydro_eukaryote
Overlapping
homologous
superfamilies
 

Description

Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipase A2, and is involved in regulation of inflammation through the inactivation of platelet-activating factor and polar phospholipids
[1, 3, 2]
.

This entry represents the platelet-activating factor acetylhydrolases from eukaryotes. It also includes the orthologue from S. pombe, the putative phospholipase A2 Pgl7.

References

1.The structure and function of platelet-activating factor acetylhydrolases. Derewenda ZS, Derewenda U. Cell. Mol. Life Sci. 54, 446-55, (1998). View articlePMID: 9645224

2.Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ 2nd. J Biol Chem 281, 4616-23, (2006). PMID: 16371369

3.Phospholipase action of platelet-activating factor acetylhydrolase, but not paraoxonase-1, on long fatty acyl chain phospholipid hydroperoxides. Kriska T, Marathe GK, Schmidt JC, McIntyre TM, Girotti AW. J Biol Chem 282, 100-8, (2007). PMID: 17090529

GO terms

biological process

  • None

cellular component

  • None

Cross References

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