F
IPR016836

Long-chain acyl-[acyl-carrier-protein] reductase

InterPro entry
Short nameAAR
Overlapping
homologous
superfamilies
 

Description

This entry represents Long-chain acyl-[acyl-carrier-protein] reductase from Synechococcus elongatus (ARR) and similar proteins from Cyanobacteria. ARR reduces a long-chain (mainly C16 or C18) fatty acyl ACP ester to its corresponding fatty aldehyde, releasing the acyl carrier protein (ACP)
[1]
. NADPH is the reductant for this reaction. Its structure shows the protein is composed of three domains, with the the mid-domain was designated as the dinucleotide recognition loop
[2]
. This enzyme may be distantly related to the short-chain dehydrogenase or reductase (SDR) family (
PF00106
).

References

1.Microbial biosynthesis of alkanes. Schirmer A, Rude MA, Li X, Popova E, del Cardayre SB. Science 329, 559-62, (2010). View articlePMID: 20671186

2.Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase. Gao Y, Zhang H, Fan M, Jia C, Shi L, Pan X, Cao P, Zhao X, Chang W, Li M. Nat Commun 11, 1525, (2020). PMID: 32251275

GO terms

biological process

  • None

cellular component

  • None

Cross References

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