F
IPR016903

Nucleolar complex-associated protein 3

InterPro entry
Short nameNucleolar_cplx-assoc_3

Description

Budding yeast nucleolar complex-associated protein 3 (Noc3) is required for initiation of DNA replication and for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm
[1, 2]
. This entry also includes Noc3 homologues from animals and plants. The mammalian Noc3 is a positive regulator in adipocyte differentiation
[3]
.

References

1.Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, Gadal O, Podtelejnikov A, Trumtel S, Gas N, Petfalski E, Tollervey D, Mann M, Hurt E, Tschochner H. Cell 105, 499-509, (2001). View articlePMID: 11371346

2.Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Zhang Y, Yu Z, Fu X, Liang C. Cell 109, 849-60, (2002). View articlePMID: 12110182

3.Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. Tominaga K, Johmura Y, Nishizuka M, Imagawa M. J. Cell. Sci. 117, 6217-26, (2004). View articlePMID: 15564382

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