F
IPR017334

Eukaryotic translation initiation factor 3 subunit G

InterPro entry
Short nameeIF3_g

Description

At least eleven different protein factors are involved in initiation of protein synthesis in eukaryotes. Binding of initiator tRNA and mRNA to the 40S subunit requires the presence of the translation initiation factors eIF-2 and eIF-3, with eIF-3 being particularly important for 80S ribosome dissociation and mRNA binding
[2]
. eIF-3 is the most complex translation inititation factor, consisting of about 13 putative subunits and having a molecular weight of between 550 - 700kDa in mammalian cells. Subunits are designated eIF-3a - eIF-3m; the large number of subunits means that the interactions between the individual subunits that make up the eIF-3 complex are complex and varied
[4]
. Subunit G is required for eIF3 integrity.

Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome
[4, 1]
. eIF3g can bind 18S rRNA
[3]
.

References

1.PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. Zhou C, Arslan F, Wee S, Krishnan S, Ivanov AR, Oliva A, Leatherwood J, Wolf DA. BMC Biol. 3, 14, (2005). View articlePMID: 15904532

2.Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes. Bommer UA, Lutsch G, Stahl J, Bielka H. Biochimie 73, 1007-19, (1991). View articlePMID: 1742346

3.Characterization of the p33 subunit of eukaryotic translation initiation factor-3 from Saccharomyces cerevisiae. Hanachi P, Hershey JW, Vornlocher HP. J. Biol. Chem. 274, 8546-53, (1999). View articlePMID: 10085088

4.Conservation and diversity of eukaryotic translation initiation factor eIF3. Asano K, Kinzy TG, Merrick WC, Hershey JW. J. Biol. Chem. 272, 1101-9, (1997). View articlePMID: 8995409

GO terms

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