IPR017463
Sulphur relay, TusD/DsrE
InterPro entry
Short name | Sulphur_relay_TusD/DsrE |
Overlapping homologous superfamilies | |
family relationships |
Description
This entry includes TusD and DsrE proteins.
The three proteins TusB, TusC, and TusD form a heterohexamer responsible for a sulphur relay reaction. In large numbers of proteobacterial species, this complex acts on a Cys-derived persulphide moiety, delivered by the cysteine desulphurase IscS to TusA, then to TusBCD. The activated sulphur group is then transferred to TusE (DsrC), then by MnmA (TrmU) for modification of an anticodon nucleotide in tRNAs for Glu, Lys, and Gln
[1].
The sulphur relay complex TusBCD is also found, under the designation DsrEFH, in phototrophic and chemotrophic sulphur bacteria, such as Chromatium vinosum or Chlorobium tepidum
[2]. In these organisms, it seems the primary purpose is related to sulphur flux, such as oxidation from sulphide to molecular sulphur to sulphate.
References
1.Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex. Numata T, Fukai S, Ikeuchi Y, Suzuki T, Nureki O. Structure 14, 357-66, (2006). View articlePMID: 16472754
2.Structural interaction between DsrE-DsrF-DsrH proteins involved in the transport of electrons in the dsr operon. Bagchi A, Ghosh TC. J. Biomol. Struct. Dyn. 25, 517-23, (2008). View articlePMID: 18282006
GO terms
biological process
molecular function
cellular component
Cross References
ENZYME
Genome Properties
Representative structure
2hy5: Crystal structure of DsrEFH