F
IPR017685

HTH-type transcriptional regulator ArgP

InterPro entry
Short nameArgP
family relationships

Description

ArgP (formally known as IciA) is a positive regulator of argK. It is a negative autoregulator in presence of arginine. It competes with DnaA for oriC iteron (13-mer) binding. It activates dnaA and nrd transcription. It has been demonstrated to be part of the pho regulon
[1]
. ArgP mutants convey canavanine (an L-arginine structural homologue) sensitivity
[2]
. ArgP also affects lysine biosynthesis in E. coli through regulating dapB Gene
[3]
.

References

1.PhoB-dependent transcriptional activation of the iciA gene during starvation for phosphate in Escherichia coli. Han JS, Park JY, Lee YS, Thony B, Hwang DS. Mol. Gen. Genet. 262, 448-52, (1999). View articlePMID: 10589831

2.Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli. Nandineni MR, Gowrishankar J. J. Bacteriol. 186, 3539-46, (2004). View articlePMID: 15150242

3.Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator. Bouvier J, Stragier P, Morales V, Remy E, Gutierrez C. J. Bacteriol. 190, 5224-9, (2008). View articlePMID: 18502871

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