C-CAP/cofactor C-like domain
Short name | C-CAP_CF_C-like |
Overlapping homologous superfamilies | |
domain relationships |
Description
* Eukaryotic cyclase-associated protein (CAP or SRV2), a modular actin monomer binding that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localisation and the establishment of cell polarity.
* Vertebrate retinitis pigmentosa 2 (XRP2). In Homo sapiens (Human), it is the protein responsible for X-linked forms of retinitis pigmentosa, a disease characterised by severe retinal degeneration.
* Eukaryotic tubulin-specific chaperone cofactor C (TBCC), a GTPase- activating component of the tubulin-folding supercomplex, which directs the assembly of the alpha- and beta-tubulin heterodimer.
References
1.Crystal structure of the actin binding domain of the cyclase-associated protein. Dodatko T, Fedorov AA, Grynberg M, Patskovsky Y, Rozwarski DA, Jaroszewski L, Aronoff-Spencer E, Kondraskina E, Irving T, Godzik A, Almo SC. Biochemistry 43, 10628-41, (2004). View articlePMID: 15311924
2.Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Kuhnel K, Veltel S, Schlichting I, Wittinghofer A. Structure 14, 367-78, (2006). View articlePMID: 16472755
3.An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport. Stephan A, Vaughan S, Shaw MK, Gull K, McKean PG. Traffic 8, 1323-30, (2007). View articlePMID: 17645436
4.Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization. Grynberg M, Jaroszewski L, Godzik A. BMC Bioinformatics 4, 46, (2003). View articlePMID: 14536023
Contributing Member Database Entry
- PROSITE profiles:PS51329