S
IPR018099

Purine phosphorylase, family 2, conserved site

InterPro entry
Short namePurine_phosphorylase-2_CS

Description

This entry consists of purine nucleoside phosphorylase (
2.4.2.1
) (PNP) that catalyses the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules
[6]
, 6-oxopurine nucleoside phosphorylase (
2.4.2.1
) that is a purine nucleoside phosphorylase specific for 6-oxopurine nucleosides
[4, 1]
, 5'-methylthioadenosine phosphorylase (
2.4.2.28
) (MTAP) that catalyses the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate
[3, 2]
and xanthosine phosphorylase (
2.4.2
) that degrades all purine nucleosides except adenosine and deoxyadenosine
[5]
.

References

1.Unraveling the structural and functional differences between purine nucleoside phosphorylase and 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus. Cacciapuoti G, Marabotti A, Fuccio F, Porcelli M. Biochim. Biophys. Acta 1814, 1358-66, (2011). View articlePMID: 21683167

2.Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta. Della Ragione F, Carteni-Farina M, Gragnaniello V, Schettino MI, Zappia V. J. Biol. Chem. 261, 12324-9, (1986). PMID: 3091600

3.Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase. Della Ragione F, Oliva A, Gragnaniello V, Russo GL, Palumbo R, Zappia V. J. Biol. Chem. 265, 6241-6, (1990). PMID: 2108157

4.Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus. Cacciapuoti G, Gorassini S, Mazzeo MF, Siciliano RA, Carbone V, Zappia V, Porcelli M. FEBS J. 274, 2482-95, (2007). View articlePMID: 17419725

5.Identification and characterization of genes (xapA, xapB, and xapR) involved in xanthosine catabolism in Escherichia coli. Seeger C, Poulsen C, Dandanell G. J. Bacteriol. 177, 5506-16, (1995). View articlePMID: 7559336

6.Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution. Ealick SE, Rule SA, Carter DC, Greenhough TJ, Babu YS, Cook WJ, Habash J, Helliwell JR, Stoeckler JD, Parks RE Jr. J. Biol. Chem. 265, 1812-20, (1990). View articlePMID: 2104852

GO terms

biological process

  • None

cellular component

  • None

Cross References

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