S
IPR018116

Somatotropin hormone, conserved site

InterPro entry
Short nameSomatotropin_CS

Description

Somatotropin is a hormone that plays an important role in growth control. It belongs to a family that includes choriomammotropin (lactogen), its placental analogue; prolactin, which promotes lactation in the mammary gland, and placental prolactin-related proteins; proliferin and proliferin related protein; and somatolactin from various fish
[1, 2, 3]
. The 3D structure of bovine somatotropin has been predicted using a combination of heuristics and energy minimisation
[4]
.

References

1.A subfamily of bovine prolactin-related transcripts distinct from placental lactogen in the fetal placenta. Kessler MA, Milosavljevic M, Zieler CG, Schuler LA. Biochemistry 28, 5154-61, (1989). View articlePMID: 2765528

2.Isolation and characterization of somatolactin, a new protein related to growth hormone and prolactin from Atlantic cod (Gadus morhua) pituitary glands. Rand-Weaver M, Noso T, Muramoto K, Kawauchi H. Biochemistry 30, 1509-15, (1991). View articlePMID: 1993170

3.Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily. Connor AM, Waterhouse P, Khokha R, Denhardt DT. Biochim. Biophys. Acta 1009, 75-82, (1989). View articlePMID: 2790033

4.A heuristic approach to predicting the tertiary structure of bovine somatotropin. Carlacci L, Chou KC, Maggiora GM. Biochemistry 30, 4389-98, (1991). View articlePMID: 2021631

GO terms

biological process

  • None
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