S
IPR018225

Transaldolase, active site

InterPro entry
Short nameTransaldolase_AS

Description

Transaldolase (
2.2.1.2
) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldolase is an enzyme of about 34kDa whose sequence has been well conserved throughout evolution. A lysine has been implicated
[1]
in the catalytic mechanism of the enzyme; it acts as a nucleophilic group that attacks the carbonyl group of fructose-6-phosphate.

References

1.Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase. Miosga T, Schaaff-Gerstenschlager I, Franken E, Zimmermann FK. Yeast 9, 1241-9, (1993). View articlePMID: 8109173

GO terms

molecular function

  • None

cellular component

  • None

Cross References

Contributing Member Database Entry
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