IPR018225
Transaldolase, active site
InterPro entry
Short name | Transaldolase_AS |
Description
Transaldolase (
2.2.1.2) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldolase is an enzyme of about 34kDa whose sequence has been well conserved throughout evolution. A lysine has been implicated
[1] in the catalytic mechanism of the enzyme; it acts as a nucleophilic group that attacks the carbonyl group of fructose-6-phosphate.
References
1.Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase. Miosga T, Schaaff-Gerstenschlager I, Franken E, Zimmermann FK. Yeast 9, 1241-9, (1993). View articlePMID: 8109173
GO terms
biological process
molecular function
- None
cellular component
- None