D
IPR018491

SLC12A transporter, C-terminal

InterPro entry
Short nameSLC12_C

Description

This entry represents a domain found in the C-terminal of the solute carrier family 12 (SLC12) members, which are K-Cl cotransporters. The SLC12 family members are predicted to have 12 transmembrane (TM) regions in a central hydrophobic domain, together with hydrophilic N- and C-termini that are likely cytoplasmic. Comparison of their sequences with those of other ion-tranporting membrane proteins reveals that they are part of a new superfamily of cation-chloride co-transporters, which includes the Na-Cl and Na-K-2Cl co-transporters
[3, 1, 2]
.

References

1.The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Rivera C, Voipio J, Payne JA, Ruusuvuori E, Lahtinen H, Lamsa K, Pirvola U, Saarma M, Kaila K. Nature 397, 251-5, (1999). View articlePMID: 9930699

2.Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter. Race JE, Makhlouf FN, Logue PJ, Wilson FH, Dunham PB, Holtzman EJ. Am. J. Physiol. 277, C1210-9, (1999). PMID: 10600773

3.Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. Payne JA, Stevenson TJ, Donaldson LF. J. Biol. Chem. 271, 16245-52, (1996). View articlePMID: 8663311

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