F
IPR019164

Transmembrane protein 147

InterPro entry
Short nameTMEM147

Description

TMEM147 is a component of the Nicalin-NOMO protein complex, which catalyzes the proteolytic cleavage of the transmembrane domain of various proteins including the beta-amyloid precursor protein and Notch
[3]
. It is a component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes
[1, 2]
.

References

1.An ER translocon for multi-pass membrane protein biogenesis. McGilvray PT, Anghel SA, Sundaram A, Zhong F, Trnka MJ, Fuller JR, Hu H, Burlingame AL, Keenan RJ. Elife 9, (2020). PMID: 32820719

2.Substrate-driven assembly of a translocon for multipass membrane proteins. Sundaram A, Yamsek M, Zhong F, Hooda Y, Hegde RS, Keenan RJ. Nature 611, 167-172, (2022). PMID: 36261522

3.Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Kruger M, Kremmer E, Haass C, Haffner C. J. Biol. Chem. 285, 26174-81, (2010). View articlePMID: 20538592

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