D
IPR019458

Telomerase activating protein Est1-like, N-terminal

InterPro entry
Short nameEst1-like_N
Overlapping
homologous
superfamilies
 

Description

Est1 is directly involved in telomere replication. It associates with telomerase and, during its interaction with CDC13, telomerase activity is promoted
[1, 2]
. This entry also includes Est1 homologues, such as human EST1A (also known as SMG6), which is essential for the replication of chromosome termini
[5]
and also plays a role in nonsense-mediated mRNA decay
[3, 4]
.

References

1.Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Taggart AK, Teng SC, Zakian VA. Science 297, 1023-6, (2002). View articlePMID: 12169735

2.The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. Evans SK, Lundblad V. Genetics 162, 1101-15, (2002). View articlePMID: 12454059

3.SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN, Izaurralde E. Genes Dev 24, 2440-50, (2010). PMID: 20930030

4.SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Eberle AB, Lykke-Andersen S, Muhlemann O, Jensen TH. Nat Struct Mol Biol 16, 49-55, (2009). PMID: 19060897

5.A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Venteicher AS, Abreu EB, Meng Z, McCann KE, Terns RM, Veenstra TD, Terns MP, Artandi SE. Science 323, 644-8, (2009). View articlePMID: 19179534

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