IPR019477
Rhodopsin, N-terminal
InterPro entry
Short name | Rhodopsin_N |
Overlapping homologous superfamilies |
Description
Rhodopsin is the archetypal G-protein-coupled receptor. Such receptors participate in virtually all physiological processes as signalling molecules. They utilise heterotrimeric guanosine triphosphate (GTP)-binding proteins to transduce extracellular signals to intracellular events. Rhodopsin is important because of the pivotal role it plays in visual signal transduction. It is a dimeric transmembrane protein whose intradiskal surface consists of an N-terminal domain and three loops connecting six of the seven transmembrane helices. The N-terminal domain is a compact α-helical region with breaks and bends at proline residues outside the membrane
[1]. This entry represents the N-terminal domain. The N-terminal domain is extracellular is and is necessary for successful dimerisation and molecular stability
[2].
References
1.Structures of the intradiskal loops and amino terminus of the G-protein receptor, rhodopsin. Yeagle PL, Salloum A, Chopra A, Bhawsar N, Ali L, Kuzmanovski G, Alderfer JL, Albert AD. J. Pept. Res. 55, 455-65, (2000). View articlePMID: 10888202
2.Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Fotiadis D, Jastrzebska B, Philippsen A, Muller DJ, Palczewski K, Engel A. Curr. Opin. Struct. Biol. 16, 252-9, (2006). View articlePMID: 16567090
Contributing Member Database Entry
- Pfam:PF10413