D
IPR019539

Galactokinase, N-terminal domain

InterPro entry
Short nameGalKase_N
Overlapping
homologous
superfamilies
 

Description

This entry represents an N-terminal conserved domain found in all galactokinases, irrespective of how many other ATP binding sites, etc that they carry
[1]
. The function of this domain appears to be to bind galactose
[2]
, and it is normally located at the N terminus of these enzymes
[3]
. It is associated with
IPR013750
and
IPR006204
. While all enzymes in this entry posses galactokinase activity, some are annotated as N-acetylgalactosamine kinases as they also posses this enzyme activity.

This domain can also be found in mevalonate kinase and related proteins from all domains of life. It can also be found in arabinose kinase from Arabidopsis
[4]
.

References

1.The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Schalkwijk J, Wiedow O, Hirose S. Biochem. J. 340 ( Pt 3), 569-77, (1999). View articlePMID: 10359639

2.Molecular structure of galactokinase. Thoden JB, Holden HM. J. Biol. Chem. 278, 33305-11, (2003). View articlePMID: 12796487

3.Galactokinase: structure, function and role in type II galactosemia. Holden HM, Thoden JB, Timson DJ, Reece RJ. Cell. Mol. Life Sci. 61, 2471-84, (2004). View articlePMID: 15526155

4.The arabinose kinase, ARA1, gene of Arabidopsis is a novel member of the galactose kinase gene family. Sherson S, Gy I, Medd J, Schmidt R, Dean C, Kreis M, Lecharny A, Cobbett C. Plant Mol. Biol. 39, 1003-12, (1999). PMID: 10344205

Cross References

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