FERM central domain
Short name | FERM_central |
Overlapping homologous superfamilies |
Description
* Band 4.1, which links the spectrin-actin cytoskeleton of erythrocytes to the plasma membrane.
* Ezrin, a component of the undercoat of the microvilli plasma membrane.
* Moesin, which is probably involved in binding major cytoskeletal structures to the plasma membrane.
* Radixin, which is involved in the binding of the barbed end of actin filaments to the plasma membrane in the undercoat of the cell- to-cell adherens junction.
* Talin, a cytoskeletal protein concentrated in regions of cell-substratum contact and, in lymphocytes, of cell-cell contacts.
* Filopodin, a slime mold protein that binds actin and which is involved in the control of cell motility and chemotaxis.
* Merlin (or schwannomin).
* Protein NBL4.
* Unconventional myosins X, VIIa and XV, which are mutated in congenital deafness.
* Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins.
* Janus tyrosine kinases (JAKs), cytoplasmic tyrosine kinases that are non-covalently associated with the cytoplasmic tails of receptors for cytokines or polypeptidic hormones.
* Non-receptor tyrosine-protein kinase TYK2.
* Protein-tyrosine phosphatases PTPN3 and PTPN4, enzyme that appear to act at junctions between the membrane and the cytoskeleton.
* Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E.
* Caenorhabditis elegans protein phosphatase ptp-1.
References
1.The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ Jr, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB. Trends Biochem. Sci. 23, 281-2, (1998). View articlePMID: 9757824
2.Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Pearson MA, Reczek D, Bretscher A, Karplus PA. Cell 101, 259-70, (2000). View articlePMID: 10847681
3.Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T. EMBO J. 19, 4449-62, (2000). View articlePMID: 10970839