D
IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain

InterPro entry
Short namePyrv/ketoisovalerate_OxRed_cat
Overlapping
homologous
superfamilies
 
domain relationships

Description

This domain is found in prokaryotes. It includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms
[1]
. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA
[1]
. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited
[2]
.

References

1.Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima. Kletzin A, Adams MW. J. Bacteriol. 178, 248-57, (1996). View articlePMID: 8550425

2.Growth of the cyanobacterium Anabaena on molecular nitrogen: NifJ is required when iron is limited. Bauer CC, Scappino L, Haselkorn R. Proc. Natl. Acad. Sci. U.S.A. 90, 8812-6, (1993). View articlePMID: 8415612

GO terms

biological process

  • None

cellular component

  • None

Cross References

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