S
IPR019796

Glucose-6-phosphate dehydrogenase, active site

InterPro entry
Short nameG6P_DH_AS

Description

Glucose-6-phosphate dehydrogenase (G6PD)
[1]
catalyses the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme
[2]
. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and is used as the pattern to identify the proteins associated with this entry.

References

1.Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure. Jeffery J, Persson B, Wood I, Bergman T, Jeffery R, Jornvall H. Eur. J. Biochem. 212, 41-9, (1993). View articlePMID: 8444164

2.Human erythrocyte glucose-6-phosphate dehydrogenase. Identification of a reactive lysyl residue labelled with pyridoxal 5'-phosphate. Camardella L, Caruso C, Rutigliano B, Romano M, Di Prisco G, Descalzi-Cancedda F. Eur. J. Biochem. 171, 485-9, (1988). View articlePMID: 3126064

GO terms

Cross References

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