IPR019796
Glucose-6-phosphate dehydrogenase, active site
InterPro entry
Short name | G6P_DH_AS |
Description
Glucose-6-phosphate dehydrogenase (G6PD)
[1] catalyses the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme
[2]. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and is used as the pattern to identify the proteins associated with this entry.
References
1.Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure. Jeffery J, Persson B, Wood I, Bergman T, Jeffery R, Jornvall H. Eur. J. Biochem. 212, 41-9, (1993). View articlePMID: 8444164
2.Human erythrocyte glucose-6-phosphate dehydrogenase. Identification of a reactive lysyl residue labelled with pyridoxal 5'-phosphate. Camardella L, Caruso C, Rutigliano B, Romano M, Di Prisco G, Descalzi-Cancedda F. Eur. J. Biochem. 171, 485-9, (1988). View articlePMID: 3126064
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PROSITE patterns:PS00069